Thursday, August 12, 2010

Q: 24 year old male presented with syncope. Patient has family history of sudden cardiac deaths in family and you strongly suspect Brugada syndrome. Which drug can be use to elicit specific EKG patterns for diagnosis of Brugada syndrome?

Answer: Flecainide

The Brugada syndrome is a genetic disorder characterised by abnormal EKG findings and an increased risk of sudden cardiac death particularly in young men without known underlying cardiac disease.

Brugada syndrome can be detected by observing characteristic patterns on an EKG, which may be present all the time, or in clinical suspicion can be elicited by the administration of Class IC antiarrhythmic drugs (like flecainide) that blocks sodium channels and causing appearance of ECG abnormalities.

Review on Brugada Syndrome at emedicine.com

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